Isaacs Syndrome

A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)

Also Known As:

Neuromyotonia; Isaacs-Mertens Syndrome; Pseudomyotonia; Acquired Neuromyotonia; Continuous Muscle Activity Syndrome; Gamstorp-Wohlfart Syndrome; Isaacs' Syndrome; Myokymia, Myotonia, Muscle Wasting, And Hyperhidrosis; Pseudomyotonia Syndrome of Isaacs; Quantal Squander; Syndrome of Continuous Muscle Activity; Continuous Myokymia; Continuous Myokymias; Gamstorp Wohlfart Syndrome; Isaac Syndrome; Isaacs Mertens Syndrome; Isaacs Pseudomyotonia Syndrome; Myokymias, Continuous; Neuromyotonia, Acquired; Myokymia, Continuous

Musculoskeletal Diseases: 719
- Muscular Diseases: 10128
  - Isaacs Syndrome: 305
Nervous System Diseases: 14178
- Neuromuscular Diseases: 2005
  - Peripheral Nervous System Diseases: 11383
    - Isaacs Syndrome: 305

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